Article
KIT activation in uterine cervix adenosquamous carcinomas by KIT/SCF autocrine/paracrine stimulation loops.
Gynecologic oncology - 1 Nov 2008
Martinho Olga, Gonçalves Alberto, Moreira Marise A R, Ribeiro Luiz F J, Queiroz Geraldo S, Schmitt Fernando C, Reis Rui M, Longatto-Filho Adhemar
Abstract excerpt
OBJECTIVES: Uterine adenosquamous carcinoma (ASC) is an uncommon, yet, one of the most aggressive cervical cancer subtype. The successful treatment of some tumors, such as gastrointestinal stromal tumors (GISTs), by anti-KIT inhibitors fosters the study of this receptor tyrosine kinase in other malignancies. In the present study, we intended to molecularly characterize KIT in ASC. METHODS: In a series of 30...
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