Article
Reappraisal of KIT mutation in adenoid cystic carcinomas of the salivary gland.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 May 2012
Sung Ji-Youn, Ahn Hee Kyung, Kwon Ji-Eun, Jeong Hansin, Baek Chung-Hwan, Son Young-Ik, Ahn Yong Chan, Park Keunchil, Ahn Myung-Ju, Ko Young-Hyeh
Abstract excerpt
BACKGROUND: While overexpression of KIT protein has been well documented in adenoid cystic carcinomas (ACCs), mutation of KIT gene has been a controversial issue. We wanted to evaluate clinical value of the KIT mutation and protein expression in ACC. METHODS: We analyzed 33 cases of ACC. Gene mutations in KIT exons 9, 11, 13, and 17 were analyzed using paraffin-embedded tissue, and two different sets of primers...
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