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Article

C-kit signaling promotes proliferation and invasion of colorectal mucinous adenocarcinoma in a murine model.

Oncotarget - 29 Sept 2015

Tan Jun, Yang Shu, Shen Ping, Sun Haimei, Xiao Jie, Wang Yaxi, Wu Bo, Ji Fengqing, Yan Jihong, Xue Hong, Zhou Deshan

Abstract excerpt

It was reported that the receptor tyrosine kinase (RTK) family often highly expressed in several mucinous carcinomas. In the present study, we established a murine model of colorectal mucinous adenocardinoma (CRMAC) by treating C57 mice [both wild type (WT) and loss-of-function c-kit mutant type (Wads-/-)] with AOM+DSS for 37 weeks and found that c-kit, a member of RTK family, clearly enhanced the tumor cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26356816
DOI: 10.18632/oncotarget.4815
PMCID: PMC4694972

Genes

ETV4
MMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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