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Article

Silent mutations in KIT and PDGFRA and coexpression of receptors with SCF and PDGFA in Merkel cell carcinoma: implications for tyrosine kinase-based tumorigenesis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2008

Kartha Reena V, Sundram Uma N

Abstract excerpt

Merkel cell carcinoma is a rare and aggressive form of skin cancer of neuroendocrine origin. Its treatment involves wide excision and radiotherapy but no effective therapy exists for advanced disease. Upregulation of the platelet-derived growth factor receptor family of tyrosine kinases, PDGFRA a...

Read the complete abstract on PubMed

Topics

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Share to Carcinoma, Merkel Cell
Share to DNA, Neoplasm
Share to Lymph Nodes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Recurrence, Local

Share to Platelet-Derived Growth Factor

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Skin Neoplasms

Source

Identifiers

PMID: 18084259
DOI: 10.1038/modpathol.3800980

Genes

KIT
PDGFRA
PDGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18084259-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Silent mutations in KIT and PDGFRA and coexpression of receptors with SCF and PDGFA in Merkel cell carcinoma: implications for tyrosine kinase-based tumorigenesis.PMID 18084259Read ↗

Platelet-derived growth factor receptor alpha mutational status and immunohistochemical expression in Merkel cell carcinoma: implications for treatment with imatinib mesylate.Semantic proximity Read ↗

Low frequency of MAP kinase pathway alterations in KIT and PDGFRA wild-type GISTs.Semantic proximity Read ↗

Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma.Semantic proximity Read ↗

Merkel cell carcinoma: evaluation of KIT (CD117) expression and failure to demonstrate activating mutations in the C-KIT proto-oncogene - implications for treatment with imatinib mesylate.Semantic proximity Read ↗

Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutations.Semantic proximity Read ↗

KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation.Semantic proximity Read ↗

Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas.Semantic proximity Read ↗

Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivitySemantic proximity Read ↗

Activating mutations in c-KIT and PDGFRalpha are exclusively found in gastrointestinal stromal tumors and not in other tumors overexpressing these imatinib mesylate target genes.Semantic proximity Read ↗

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Merkel cell carcinoma: correlation of KIT expression with survival and evaluation of KIT gene mutational statusSemantic proximity Read ↗

KIT (CD117) Expression in Benign and Malignant Sweat Gland Tumors.Semantic proximity Read ↗

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