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Article

Targeting c-Kit mutations: basic science to novel therapies.

Leukemia research - 1 May 2004

Sattler Martin, Salgia Ravi

Abstract excerpt

The Kit receptor tyrosine kinase is a transmembrane receptor that is expressed in a variety of different tissues and mediates pleiotropic biological effects through its ligand stem cell factor (SCF). Sporadic mutations of Kit as well as autocrine/paracrine activation mechanisms of the SCF/Kit pathway have been implicated in a variety of malignancies, where its primary contribution to metastases is in enhancing...

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Identifiers

PMID: 15036937
DOI: 10.1016/j.leukres.2003.10.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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