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Article

KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors.

Biochemical and biophysical research communications - 11 Nov 2005

Nakai Yasutomo, Nonomura Norio, Oka Daizo, Shiba Masayuki, Arai Yasuyuki, Nakayama Masashi, Inoue Hitoshi, Nishimura Kazuo, Aozasa Katsuyuki, Mizutani Yoichi, Miki Tsuneharu, Okuyama Akihiko

Abstract excerpt

We investigated the expression of KIT (product of c-kit oncogene), gain-of-function mutations, and activation of its downstream signal transduction in human testicular cancers. KIT was expressed in 88% (22/25) of seminomas and in 44.4% (4/9) of non-seminomas compared to adjacent normal testicular tissue. Nine of the KIT-expressing seminomas had mutations (40.9%; 9/22) in the c-kit gene; two cases in exon 11 and 7...

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Source

Identifiers

PMID: 16188233
DOI: 10.1016/j.bbrc.2005.09.042

Genes

KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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