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Article

Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Mar 2002

Heinrich Michael C, Blanke Charles D, Druker Brian J, Corless Christopher L

Abstract excerpt

PURPOSE: Activation of the KIT tyrosine kinase by somatic mutation has been documented in a number of human malignancies, including gastrointestinal stromal tumor (GIST), seminoma, acute myelogenous leukemia (AML), and mastocytosis. In addition, paracrine or autocrine activation of this kinase ha...

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Source

Identifiers

PMID: 11896121
DOI: 10.1200/JCO.2002.20.6.1692

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11896121-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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