Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tgf-beta signaling alterations and colon cancer.

Cancer treatment and research - 1 Jan 2010

Bellam Naresh, Pasche Boris

Abstract excerpt

Colorectal cancer is the second most common cause of cancer-related death in the United States. Twin studies suggest that 35% of all colorectal cancer cases are inherited. High-penetrance tumor susceptibility genes account for at most 3-6% of all colorectal cancer cases and the remainder of the unexplained risk is likely due to a combination of low to moderate penetrance genes. Recent genome-wide association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Carcinoma
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Serine-Threonine Kinases

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Receptors, Transforming Growth Factor beta

Share to Smad Proteins

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 20517689
DOI: 10.1007/978-1-4419-6033-7_5

Genes

GREM1
SMAD4
SMAD7
TGFBR1
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tgf-beta signaling alterations and colon cancer.PMID 20517689Read ↗

TGF-beta signaling alterations and susceptibility to colorectal cancer.Semantic proximity Read ↗

TGF-beta signalling in colon carcinogenesis.Semantic proximity Read ↗

Genetic variation in the TGF-β signaling pathway and colon and rectal cancer risk.Semantic proximity Read ↗

Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor MicroenvironmentSemantic proximity Read ↗

Investigating the WNT and TGF-beta pathways alterations and tumor mutant burden in young-onset colorectal cancer.Semantic proximity Read ↗

New insights into the aetiology of colorectal cancer from genome-wide association studies.Semantic proximity Read ↗

TGFBR1 and cancer susceptibility.Semantic proximity Read ↗

TGFβ and the Tumor Microenvironment in Colorectal CancerSemantic proximity Read ↗

Transforming Growth Factor β Superfamily Signaling in Development of Colorectal CancerSemantic proximity Read ↗

Genetic and epigenetic alterations in colon cancer.Semantic proximity Read ↗

Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements.Semantic proximity Read ↗

Genetic variants in the TGFβ-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.