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Article

Role of the prostanoid FP receptor in action potential generation and phenotypic transformation of NRK fibroblasts.

Cellular signalling - 1 Nov 2008

Almirza W H, Dernison M M, Peters P H J, van Zoelen E J J, Theuvenet A P R

Abstract excerpt

By using an shRNA approach to knockdown the expression of the prostaglandin (PG)-F(2alpha) receptor (FP-R), the role of PGF(2alpha) in the process of phenotypic transformation of normal rat kidney (NRK) fibroblasts has been studied. Our data show that PGF(2alpha) up-regulates Cox-2 expression both at the mRNA and protein level, indicating that activation of FP-R in NRK fibroblasts induces a positive feedback loop...

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Source

Identifiers

PMID: 18703136
DOI: 10.1016/j.cellsig.2008.07.013

Genes

NRK
PGF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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