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Article

Influence of cell type on the steroidogenic potential and basal cyclic AMP levels of ras-oncogene-transformed rat cells.

Differentiation; research in biological diversity - 1 Jun 1995

Pan J, Roskelley C D, Auersperg N

Abstract excerpt

Transformation with ras oncogenes causes loss, maintenance or modulation of differentiation, depending on the developmental history of the target cells. In the present study, we examined steps in signal transduction that may underlie some of this variation, using steroidogenic cells of adult rats as the model system. Steroidogenesis in normal cells is regulated by cyclic AMP and protein kinase A (the cAMP/PKA...

Topics

Animals
Basal Metabolism
Cell Transformation, Neoplastic
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Genes, ras
Phenotype
Pregnenolone
Progesterone
Rats
Rats, Inbred F344

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Steroids

Source

Identifiers

PMID: 7622009
DOI: 10.1046/j.1432-0436.1995.5850321.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7622009-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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