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Article

Autocrine production of prostaglandin F2alpha enhances phenotypic transformation of normal rat kidney fibroblasts.

American journal of physiology. Cell physiology - 1 Jul 2005

Harks E G A, Peters P H J, van Dongen J L J, van Zoelen E J J, Theuvenet A P R

Abstract excerpt

We have used normal rat kidney (NRK) fibroblasts as an in vitro model system to study cell transformation. These cells obtain a transformed phenotype upon stimulation with growth-modulating factors such as retinoic acid (RA) or transforming growth factor-beta (TGF-beta). Patch-clamp experiments showed that transformation is paralleled by a profound membrane depolarization from around -70 to -20 mV. This...

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Identifiers

PMID: 15758043
DOI: 10.1152/ajpcell.00416.2004

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NRK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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