Article
Lysophosphatidic acid and bradykinin have opposite effects on phenotypic transformation of normal rat kidney cells.
Journal of cellular biochemistry - 1 Dec 1994
Afink G B, Van Alewijk D C, De Roos A D, Van Zoelen E J
Abstract excerpt
The bioactive lipid lysophosphatidic acid is besides a strong mitogen for quiescent fibroblasts, a potent inducer of phenotypic transformation of normal rat kidney cells. The lysophosphatidic acid induced loss of density-arrest is strongly inhibited by bradykinin. Although their effects on normal rat kidney cell proliferation are opposite, bradykinin mimics many of the intracellular effects induced upon...
Topics
- Animals
- Arachidonic Acid
- Bradykinin
- Calcium
- Cell Line, Transformed
- ErbB Receptors
- Growth Inhibitors
- Kidney
- Lysophospholipids
- Phenotype
- Prostaglandin-Endoperoxide Synthases