Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EP<sub>2</sub>receptor mediates PGE<sub>2</sub>-induced cystogenesis of human renal epithelial cells

30 Aug 2007

Abstract excerpt

Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by formation of cysts from tubular epithelial cells. Previous studies indicate that secretion of prostaglandin E2 (PGE2) into cyst fluid and production of cAMP underlie cyst expansion. However, the mechanism by which PGE2 directly stimulates cAMP formation and modulates cystogenesis is still unclear, because the particular E-prostanoid (EP)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bladder and Urothelial Cancer Treatments
Share to Genetic and Kidney Cyst Diseases
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17728378
DOI: 10.1152/ajprenal.00036.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EP<sub>2</sub>receptor mediates PGE<sub>2</sub>-induced cystogenesis of human renal epithelial cellsPMID 17728378Read ↗

The genetics and physiology of polycystic kidney disease.Semantic proximity Read ↗

Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial CellsSemantic proximity Read ↗

EZH2 inhibition or genetic ablation suppresses cyst growth in autosomal dominant polycystic kidney diseaseSemantic proximity Read ↗

Prostaglandin E <sub>1</sub> as therapeutic molecule for Nephronophthisis and related ciliopathiesSemantic proximity Read ↗

Inhibition of the P2X7 receptor reduces cystogenesis in PKD.Semantic proximity Read ↗

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.Semantic proximity Read ↗

Cytosolic phospholipase A2α increases proliferation and de-differentiation of human renal tubular epithelial cells.Semantic proximity Read ↗

NHA2 promotes cyst development in an <i>in vitro</i> model of polycystic kidney diseaseSemantic proximity Read ↗

CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation.Semantic proximity Read ↗

Prostaglandin E2 Induces Fibroblast Growth Factor 9 via EP3-Dependent Protein Kinase Cδ and Elk-1 SignalingSemantic proximity Read ↗

Strategies to inhibit cyst formation in ADPKD.Semantic proximity Read ↗

PKD2 functions as an epidermal growth factor-activated plasma membrane channel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.