Article
Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism.
The EMBO journal - 1 Jul 1996
Alblas J, van Etten I, Moolenaar W H
Abstract excerpt
We have used the neurokinin NK-2 receptor as a model to examine how receptor desensitization affects cellular responses. The liganded receptor transiently activates phospholipase C (PLC) and is rapidly phosphorylated on Ser/Thr residues in its C-terminal domain. Mutant receptors lacking this doma...
Topics
- ADP Ribose Transferases
- Animals
- Botulinum Toxins
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Enzyme Activation
- Hydrolysis
- Phenotype
- Phosphatidylinositols
- Phosphorylation
- Protein Kinases
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf
- Rats
- Receptors, Neurokinin-2
- Tyrosine