Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism.

The EMBO journal - 1 Jul 1996

Alblas J, van Etten I, Moolenaar W H

Abstract excerpt

We have used the neurokinin NK-2 receptor as a model to examine how receptor desensitization affects cellular responses. The liganded receptor transiently activates phospholipase C (PLC) and is rapidly phosphorylated on Ser/Thr residues in its C-terminal domain. Mutant receptors lacking this domain mediate persistent activation of PLC. We now show that, in transfected Rat-1 cells, mutant receptor mediates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cell Line
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Phenotype

Share to Phosphorylation

Share to Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8670836
PMCID: PMC451898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism.PMID 8670836Read ↗

C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. Role of receptor phosphorylation in signal attenuation.Semantic proximity Read ↗

NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype.Semantic proximity Read ↗

Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis.Semantic proximity Read ↗

Mutations in the extracellular amino-terminal domain of the NK2 neurokinin receptor abolish cAMP signaling but preserve intracellular calcium responses.Semantic proximity Read ↗

Transformation of breast cells by truncated neurokinin-1 receptor is secondary to activation by preprotachykinin-A peptidesSemantic proximity Read ↗

A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization.Semantic proximity Read ↗

A dominant role of the juxtamembrane region of the TrkA nerve growth factor receptor during neuronal cell differentiation.Semantic proximity Read ↗

Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation.Semantic proximity Read ↗

Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta.Semantic proximity Read ↗

Rescuing the traffic-deficient mutants of rat mu-opioid receptors with hydrophobic ligands.Semantic proximity Read ↗

Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting.Semantic proximity Read ↗

Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.