Article
Phenotypic transformation of normal rat kidney fibroblasts by endothelin-1. Different mode of action from lysophosphatidic acid, bradykinin, and prostaglandin f2alpha.
Biochimica et biophysica acta - 8 Mar 1999
Lahaye D H, Walboomers F, Peters P H, Theuvenet A P, Van Zoelen E J
Abstract excerpt
In the present study, we compared the effects of endothelin (ET)-1 on cell proliferation and second messenger induction in normal rat kidney (NRK) fibroblasts, with those of other activators of G-protein-coupled receptors such as prostaglandin (PG)-F2alpha, bradykinin (BK), and lysophosphatidic acid (LPA). LPA is mitogenic by itself, while the other factors require the presence of EGF. In density-arrested NRK...
Topics
- Animals
- Arachidonic Acid
- Bradykinin
- Calcium
- Cell Division
- Cells, Cultured
- Dinoprost
- Endothelin-1
- Epidermal Growth Factor
- Fibroblasts
- Kidney
- Lysophospholipids
- Mitogens
- Patch-Clamp Techniques
- Phenotype
- Rats