Article
Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation.
Molecular and cellular biology - 1 Jan 1997
Fanger G R, Vaillancourt R R, Heasley L E, Montmayeur J P, Johnson G L, Maue R A
Abstract excerpt
The mechanisms governing neuronal differentiation, including the signals underlying the induction of voltage-dependent sodium (Na+) channel expression by neurotrophic factors, which occurs independent of Ras activity, are not well understood. Therefore, Na+ channel induction was analyzed in subli...
Topics
- Animals
- Becaplermin
- Cell Differentiation
- GTPase-Activating Proteins
- Humans
- Intracellular Signaling Peptides and Proteins
- Isoenzymes
- Matrix Metalloproteinase 3
- Mutation
- Nerve Growth Factors
- Neurites
- Neurons
- PC12 Cells
- Patch-Clamp Techniques