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Article

DNA sequence variants of the FKBP5 gene are associated with unipolar depression.

The international journal of neuropsychopharmacology - 1 Jun 2010

Zobel Astrid, Schuhmacher Anna, Jessen Frank, Höfels Susanne, von Widdern Olrik, Metten Martin, Pfeiffer Ute, Hanses Claudia, Becker Tim, Rietschel Marcella, Scheef Lukas, Block Wolfgang, Schild Hans H, Maier Wolfgang, Schwab Sibylle G

Abstract excerpt

FKBP5 is a glucocorticoid receptor-regulating co-chaperone of hsp-90 and, therefore, is suggested to play a role in the regulation of the hypothalamic-pituitary-adrenocortical system and the pathophysiology of depression. Previously, three studies identified single nucleotide polymorphisms (SNPs) in the FKBP5 gene associated with response to antidepressants, and one study found an association with diagnosis of...

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Identifiers

PMID: 20047716
DOI: 10.1017/S1461145709991155

Genes

FKBP5
CRH

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DNA sequence variants of the FKBP5 gene are associated with unipolar depression.PMID 20047716Read ↗

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The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral PhenotypesSemantic proximity Read ↗

Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits.Semantic proximity Read ↗

Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.Semantic proximity Read ↗

The association of FKBP5 gene polymorphism with genetic susceptibility to depression and response to antidepressant treatment- a systematic review.Semantic proximity Read ↗

FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder.Semantic proximity Read ↗

The Role of FKBP5 in Mood Disorders: Action of FKBP5 on Steroid Hormone Receptors Leads to Questions About its Evolutionary ImportanceSemantic proximity Read ↗

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