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Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders

3 Oct 2024

Abstract excerpt

The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in governing stress-related disorders such as major depressive disorder (MDD), anxiety, and post-traumatic stress disorder. Chronic stress or early life trauma, known risk factors of disease, alter HPA axis activity and pattern of glucocorticoid (GC) secretion. These changes have consequences for physiological processes controlled by...

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PMID: 39361217
DOI: 10.1007/s43440-024-00654-w

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