Effect of the common functional FKBP5 variant (rs1360780) on the hypothalamic-pituitary-adrenal axis and peripheral blood gene expression.

doi:10.1016/j.psyneuen.2014.01.007

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Article

Effect of the common functional FKBP5 variant (rs1360780) on the hypothalamic-pituitary-adrenal axis and peripheral blood gene expression.

Psychoneuroendocrinology - 1 Apr 2014

Fujii Takashi, Hori Hiroaki, Ota Miho, Hattori Kotaro, Teraishi Toshiya, Sasayama Daimei, Yamamoto Noriko, Higuchi Teruhiko, Kunugi Hiroshi

Abstract excerpt

Regulation of hypothalamic-pituitary-adrenal (HPA) axis reactivity plays an important role in the development of stress-related psychiatric disorders. FK506 binding protein 5 (FKBP5) modulates HPA axis reactivity via glucocorticoid receptor (GR; NR3C1) sensitivity and signaling. The T allele of the single nucleotide polymorphism, FKBP5 rs1360780 (C/T), is associated with higher FKBP5 induction by glucocorticoids....

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PMID: 24636505
DOI: 10.1016/j.psyneuen.2014.01.007

Genes

FKBP5
CRH

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