Article
Exclusive KRAS mutation in microsatellite-unstable human colorectal carcinomas with sequence alterations in the DNA mismatch repair gene, MLH1.
Gene - 1 Nov 2008
Zhao Yan, Miyashita Kaname, Ando Takayuki, Kakeji Yoshihiro, Yamanaka Takeharu, Taguchi Kenichi, Ushijima Toshikazu, Oda Shinya, Maehara Yoshihiko
Abstract excerpt
Microsatellite instability (MSI) is regarded as reflecting defective DNA mismatch repair (MMR). MMR defects lead to an increase in point mutations, as well as repeat instability, on the genome. However, despite the highly unstable microsatellites, base substitutions in representative oncogenes or tumor suppressors are extremely infrequent in MSI-positive tumors. Recently, the heterogeneity in MSI-positive...
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