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Article

KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers.

Advances in cancer research - 1 Jan 2010

Velho Sérgia, Corso Giovanni, Oliveíra Carla, Seruca Raquel

Abstract excerpt

Microsatellite instability (MSI) occurs in about 15% of gastrointestinal cancers and it is associated with specific clinic, pathologic, and molecular features of the tumors. MSI-high (MSI-H) carcinomas also follow specific tumor development pathways. This review is focused on the molecular profile of alterations in members of the KRAS signaling pathway (EGFR, KRAS, BRAF, PIK3CA, RASSF1A, and MLK3 genes) in MSI...

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Source

Identifiers

PMID: 21070916
DOI: 10.1016/B978-0-12-380890-5.00004-1

Genes

KRAS
BRAF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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