Article
Colorectal serrated adenocarcinoma shows a different profile of oncogene mutations, MSI status and DNA repair protein expression compared to conventional and sporadic MSI-H carcinomas.
International journal of cancer - 15 Oct 2012
García-Solano J, Conesa-Zamora P, Carbonell P, Trujillo-Santos J, Torres-Moreno D D, Pagán-Gómez I, Rodríguez-Braun E, Pérez-Guillermo M
Abstract excerpt
Molecular characterization has been extensively studied in serrated polyps but very little is known in serrated adenocarcinomas (SACs). We analyzed the incidence of KRAS, BRAF and PIK3CA mutations, microsatellite instability (MSI) status and loss of the DNA repair proteins MLH1, MSH2, MSH6 and MGMT in a series of 89 SAC, 81 matched conventional carcinomas (CC) and 13 sporadic colorectal cancer showing...
Topics
- Adenocarcinoma
- Adenoma
- Aged
- Biomarkers, Tumor
- Class I Phosphatidylinositol 3-Kinases
- Colorectal Neoplasms
- DNA Methylation
- DNA Repair Enzymes
- Female
- Follow-Up Studies