Article
Microsatellite instability in colorectal cancer.
Gastroenterology - 1 Jun 2010
Boland C Richard, Goel Ajay
Abstract excerpt
Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of these are associated with Lynch syndrome and the other 12% are caused by sporadic, acquired hypermethylation of the promoter of the MLH1 gene, which occurs in tumors with the CpG island methylator phenotype. Colorectal tumors with MSI...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.