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Article

Microsatellite instability in colorectal cancer.

17 Dec 2018

Abstract excerpt

Microsatellites are short tandem repeat DNA sequences of one to tetra base pairs distributed throughout the human genome, both in coding and non-coding regions. Owing to their repeated structure, microsatellites are particularly prone to replication errors that are normally repaired by the Mismatch Repair (MMR) system. MMR is a very highly conserved cellular process, involving many proteins, resulting in the...

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PMID: 30561401
DOI: 10.23750/abm.v89i9-s.7960

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