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Article

Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications.

Cellular oncology (Dordrecht, Netherlands) - 1 Jun 2011

Zaanan Aziz, Meunier Katy, Sangar Fatiha, Fléjou Jean-François, Praz Françoise

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) constitutes an important oncogenic molecular pathway in colorectal cancer (CRC), representing approximately 15% of all colorectal malignant tumours. In roughly one third of the cases, the underlying DNA mismatch repair (MMR) defect is inherited through the transmission of a mutation in one of the genes involved in MMR, predominantly MSH2 and MLH1, or less frequently,...

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Source

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Identifiers

PMID: 21484480
DOI: 10.1007/s13402-011-0024-x
PMCID: PMC13014579

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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