Article
Colorectal carcinogenesis: MSI-H versus MSI-L.
Disease markers - 1 Jan 2004
Pawlik Timothy M, Raut Chandrajit P, Rodriguez-Bigas Miguel A
Abstract excerpt
Microsatellite instability (MSI) is a well-recognized phenomenon that is classically a feature of tumors in the hereditary non-polyposis colorectal syndrome. Ten to 15% of sporadic colorectal cancers, however, will have MSI. Microsatellite unstable tumors can be divided into two distinct MSI phenotypes: MSI-high (MSI-H) and MSI-low (MSI-L). MSI sporadic colorectal cancers with a high level of MSI (MSI-H) form a...
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