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Article

Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.

Genes & development - 1 Mar 2005

Isono Kyoichi, Mizutani-Koseki Yoko, Komori Toshihisa, Schmidt-Zachmann Marion S, Koseki Haruhiko

Abstract excerpt

Polycomb group (PcG) proteins are responsible for the stable repression of homeotic (Hox) genes by forming multimeric protein complexes. We show (1) physical interaction between components of the U2 small nuclear ribonucleoprotein particle (U2 snRNP), including Sf3b1 and PcG proteins Zfp144 and Rnf2; and (2) that Sf3b1 heterozygous mice exhibit skeletal transformations concomitant with ectopic Hox expressions....

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Identifiers

PMID: 15741318
DOI: 10.1101/gad.1284605
PMCID: PMC551574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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