Article
Positional cloning of a global regulator of anterior-posterior patterning in mice.
Nature - 19 Sept 1996
Shumacher A, Faust C, Magnuson T
Abstract excerpt
Anterior-posterior (A-P) patterning is of fundamental importance throughout vertebrate embryonic development. Murine members of the trithorax (trx) and Polycomb group (Pc-G) of genes regulate A-P patterning of segmented axial structures, demonstrating conserved upstream regulation of homeotic pat...
Topics
- Amino Acid Sequence
- Animals
- Cloning, Molecular
- CpG Islands
- Drosophila
- Drosophila Proteins
- Embryonic and Fetal Development
- Gene Expression Regulation, Developmental
- Histone-Lysine N-Methyltransferase
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Morphogenesis
- Mutation
- Polycomb Repressive Complex 1
- Polycomb Repressive Complex 2
- Proteins
- Sequence Homology, Amino Acid