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Article

Positional cloning of a global regulator of anterior-posterior patterning in mice.

Nature - 19 Sept 1996

Shumacher A, Faust C, Magnuson T

Abstract excerpt

Anterior-posterior (A-P) patterning is of fundamental importance throughout vertebrate embryonic development. Murine members of the trithorax (trx) and Polycomb group (Pc-G) of genes regulate A-P patterning of segmented axial structures, demonstrating conserved upstream regulation of homeotic pathways between Drosophila and mouse. Here we report the positional cloning of a classical mouse mutation, eed (for...

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PMID: 8805699
DOI: 10.1038/383250a0

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