Article
Cold-inducible RNA binding protein (CIRP), a novel XTcf-3 specific target gene regulates neural development in Xenopus.
BMC developmental biology - 7 Aug 2008
van Venrooy Stephanie, Fichtner Dagmar, Kunz Martin, Wedlich Doris, Gradl Dietmar
Abstract excerpt
BACKGROUND: As nuclear mediators of wnt/beta-catenin signaling, Lef/Tcf transcription factors play important roles in development and disease. Although it is well established, that the four vertebrate Lef/Tcfs have unique functional properties, most studies unite Lef-1, Tcf-1, Tcf-3 and Tcf-4 and reduce their function to uniformly transduce wnt/beta-catenin signaling for activating wnt target genes. In order to...
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