Article
FRL-1, a member of the EGF-CFC family, is essential for neural differentiation in Xenopus early development.
Development (Cambridge, England) - 1 May 2003
Yabe Shin-Ichiro, Tanegashima Kousuke, Haramoto Yoshikazu, Takahashi Shuji, Fujii Tomoyuki, Kozuma Siro, Taketani Yuji, Asashima Makoto
Abstract excerpt
Recent studies indicate an essential role for the EGF-CFC family in vertebrate development, particularly in the regulation of nodal signaling. Biochemical evidence suggests that EGF-CFC genes can also activate certain cellular responses independently of nodal signaling. Here, we show that FRL-1, a Xenopus EGF-CFC gene, suppresses BMP signaling to regulate an early step in neural induction. Overexpression of FRL-1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.