Article
Two tcf3 genes cooperate to pattern the zebrafish brain.
Development (Cambridge, England) - 1 May 2003
Dorsky Richard I, Itoh Motoyuki, Moon Randall T, Chitnis Ajay
Abstract excerpt
Caudalizing factors operate in the context of Wnt/beta-catenin signaling to induce gene expression in discrete compartments along the rostral-caudal axis of the developing vertebrate nervous system. In zebrafish, basal repression of caudal genes is achieved through the function of Headless (Hdl), a Tcf3 homolog. In this study, we show that a second Tcf3 homolog, Tcf3b, limits caudalization caused by loss of Hdl...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.