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Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development

26 Jun 2006

Abstract excerpt

Regulatory factor X4 variant transcript 3 (Rfx4_v3) gene disruption in mice demonstrated that interruption of a single allele (heterozygous, +/-) prevented formation of the subcommissural organ, resulting in congenital hydrocephalus, while interruption of two alleles (homozygous, -/-) caused fatal failure of dorsal midline brain structure formation. To identify potential target genes for RFX4_v3, we used...

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PMID: 16893423
DOI: 10.1111/j.1471-4159.2006.03930.x

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