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Article

Small-ruminant lentivirus enhances PrPSc accumulation in cultured sheep microglial cells.

Journal of virology - 1 Oct 2008

Stanton James B, Knowles Donald P, O'Rourke Katherine I, Herrmann-Hoesing Lynn M, Mathison Bruce A, Baszler Timothy V

Abstract excerpt

Sheep scrapie is the prototypical transmissible spongiform encephalopathy (prion disease), which has a fundamental pathogenesis involving conversion of normal cellular prion protein (PrP(C) [C superscript stands for cellular]) to disease-associated prion protein (PrP(Sc) [Sc superscript stands for sheep scrapie]). Sheep microglial cell cultures, derived from a prnp 136VV/171QQ near-term fetal brain, were...

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Identifiers

PMID: 18684809
DOI: 10.1128/JVI.01137-08
PMCID: PMC2566263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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