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Article

Biology of PrPsc accumulation in two natural scrapie-infected sheep flocks.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc - 1 Nov 2004

Caplazi Patrick, O'Rourke Katherine, Wolf Cynthia, Shaw Daniel, Baszler Timothy V

Abstract excerpt

Sheep scrapie is a prion disease that requires interaction of exogenous prions with host prion protein (PrP) supporting prion formation. Disease is associated with deposition of a host-generated conformational variant of PrP, PrPsc, in a variety of tissues, including brain, resulting in fatal spongiform encephalopathy. Efficiency of PrPsc formation is determined by polymorphisms in the PrP-coding sequence. This...

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Identifiers

PMID: 15586562
DOI: 10.1177/104063870401600601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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