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Article

Ex vivo propagation of infectious sheep scrapie agent in heterologous epithelial cells expressing ovine prion protein.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2001

Vilette D, Andreoletti O, Archer F, Madelaine M F, Vilotte J L, Lehmann S, Laude H

Abstract excerpt

Transmissible spongiform encephalopathies, or prion diseases, are fatal degenerative disorders of the central nervous system that affect humans and animals. Prions are nonconventional infectious agents whose replication depends on the host prion protein (PrP). Transmission of prions to cultured c...

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Identifiers

PMID: 11259656
DOI: 10.1073/pnas.061337998
PMCID: PMC31178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11259656-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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