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Article

Prion infection of mouse neurospheres.

Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2006

Giri Ranjit K, Young Rebecca, Pitstick Rose, DeArmond Stephen J, Prusiner Stanley B, Carlson George A

Abstract excerpt

Only a few cell lines have been infected with prions, offering limited genetic diversity and sensitivity to several strains. Here we report that cultured neurospheres expressing cellular prion protein (PrP(C)) can be infected with prions. Neurosphere lines isolated from the brains of mice at embryonic day 13-15 grow as aggregates and contain CNS stem cells. We produced neurosphere cultures from FVB/NCr (FVB)...

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Source

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Identifiers

PMID: 16495413
DOI: 10.1073/pnas.0510902103
PMCID: PMC1533787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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