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Article

Transcriptomic Determinants of Scrapie Prion Propagation in Cultured Ovine Microglia.

PloS one - 1 Jan 2016

Muñoz-Gutiérrez Juan F, Pierlé Sebastián Aguilar, Schneider David A, Baszler Timothy V, Stanton James B

Abstract excerpt

Susceptibility to infection by prions is highly dependent on the amino acid sequence and host expression of the cellular prion protein (PrPC); however, cellular expression of a genetically susceptible PrPC is insufficient. As an example, it has been shown in cultured cells that permissive and resistant sublines derived from the same parental population often have similar expression levels of PrPC. Thus,...

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Identifiers

PMID: 26807844
DOI: 10.1371/journal.pone.0147727
PMCID: PMC4726464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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