Article
Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Oct 2002
Andréoletti Olivier, Berthon Patricia, Levavasseur Etienne, Marc Daniel, Lantier Frédéric, Monks Eoin, Elsen Jean-Michel, Schelcher François
Abstract excerpt
Transmissible spongiform encephalopathies are fatal neurodegenerative diseases characterized by amyloid deposition of protein-prion (PrPsc), the pathogenic isoform of the host cellular protein PrPc, in the immune and central nervous systems. In the absence of definitive data on the nature of the infectious agent, PrPsc immunohistochemistry (IHC) constitutes one of the main methodologies for pathogenesis studies...
Topics
- Animals
- Antibody Specificity
- Antigens, CD
- Astrocytes
- B-Lymphocytes
- Brain
- Cell Division
- Cross Reactions
- Dendritic Cells
- Immunohistochemistry