Article
Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Feb 2012
Umemura Takeji, Joshita Satoru, Ichijo Tetsuya, Yoshizawa Kaname, Katsuyama Yoshihiko, Tanaka Eiji, Ota Masao
Abstract excerpt
UNLABELLED: Along with twin and family studies, recent genome-wide association studies suggest that genetic factors contribute to the susceptibility and severity of primary biliary cirrhosis (PBC). Although several reports have demonstrated that the human leukocyte antigen (HLA) DRB1*08:03 allele is associated with disease susceptibility in Japan, the precise analysis of HLA haplotypes and the role of amino acid...
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