Article
Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C>T, BCL2-938C>A, MCL1-386C>G) in extrahepatic cholangiocarcinoma.
Cancer investigation - 1 Jun 2010
Fingas Christian Dominik, Katsounas Antonios, Kahraman Alisan, Siffert Winfried, Jochum Christoph, Gerken Guido, Nückel Holger, Canbay Ali
Abstract excerpt
BACKGROUND/AIMS: Cholangiocellular carcinoma (CCA) has a devastating prognosis and markers enabling a precise prediction of the clinical outcome have long remained scarce. Recently, it has been demonstrated that genotype distribution of several single-nucleotide polymorphisms (SNPs) in genes that modulate G protein-signal transduction and apoptosis can serve as helpful predictive parameters in various carcinomas....
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