Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis.

doi:10.1007/s00251-020-01192-4

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Replication study and meta-analysis indicate a suggestive association of RUNX3 locus with primary biliary cholangitis.

Immunogenetics - 1 Dec 2020

Jawed Rohil, Zhang Mingming, Wang Chan, Yang Shu-Han, Jiang Peng, Wu Qiuyuan, Li Li, Chen Weichang, Gershwin M Eric, Tian Ye, Seldin Michael F, Ma Xiong, Liu Xiangdong, Lian Zhe-Xiong, Shi Xingjuan

Abstract excerpt

Susceptibility to primary biliary cholangitis (PBC) is in part genetically determined. In our previous PBC genome-wide association study (GWAS) in 1118 Han Chinese PBC and 4036 controls, we noted that multiple SNPs in the runt-related transcription factor 3 (RUNX3) regions showed a nominally significant association. The tag SNP rs7529070 was genotyped using a TaqMan assay in a separately collected 1435 PBC and...

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PMID: 33284381
DOI: 10.1007/s00251-020-01192-4

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