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Article

A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis.

BMC genomics - 31 Jul 2008

Gayán Javier, González-Pérez Antonio, Bermudo Fernando, Sáez María Eugenia, Royo Jose Luis, Quintas Antonio, Galan Jose Jorge, Morón Francisco Jesús, Ramirez-Lorca Reposo, Real Luis Miguel, Ruiz Agustín

Abstract excerpt

BACKGROUND: The difficulty in elucidating the genetic basis of complex diseases roots in the many factors that can affect the development of a disease. Some of these genetic effects may interact in complex ways, proving undetectable by current single-locus methodology. RESULTS: We have developed an analysis tool called Hypothesis Free Clinical Cloning (HFCC) to search for genome-wide epistasis in a case-control...

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Identifiers

PMID: 18667089
DOI: 10.1186/1471-2164-9-360
PMCID: PMC2533022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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