Primer in Genetics and Genomics, Article 7-Multifactorial Concepts: Gene-Gene Interactions.

Abstract excerpt

Most common disorders affecting human health are not attributable to simple Mendelian (single-gene) inheritance patterns. Rather, the risk of developing a complex disease is often the result of interactions across genes, whereby one gene modifies the phenotype of another gene. These types of interactions can occur between two or more genes and are referred to as epistasis. There are five major types of epistatic...

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