Article
A powerful and efficient two-stage method for detecting gene-to-gene interactions in GWAS.
Biostatistics (Oxford, England) - 1 Jul 2017
Pecanka Jakub, Jonker Marianne A, Bochdanovits Zoltan, Van Der Vaart Aad W
Abstract excerpt
For over a decade functional gene-to-gene interaction (epistasis) has been suspected to be a determinant in the "missing heritability" of complex traits. However, searching for epistasis on the genome-wide scale has been challenging due to the prohibitively large number of tests which result in a serious loss of statistical power as well as computational challenges. In this article, we propose a two-stage method...
Topics
- Epistasis, Genetic
- Genome-Wide Association Study
- Genotype
- Humans
- Polymorphism, Single Nucleotide
- Software