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An exhaustive epistatic SNP association analysis on expanded Wellcome Trust data.

Scientific reports - 1 Jan 2013

Lippert Christoph, Listgarten Jennifer, Davidson Robert I, Baxter Scott, Poon Hoifung, Poong Hoifung, Kadie Carl M, Heckerman David

Abstract excerpt

We present an approach for genome-wide association analysis with improved power on the Wellcome Trust data consisting of seven common phenotypes and shared controls. We achieved improved power by expanding the control set to include other disease cohorts, multiple races, and closely related individuals. Within this setting, we conducted exhaustive univariate and epistatic interaction association analyses. Use of...

Topics

Cohort Studies
Crohn Disease
Data Interpretation, Statistical
Epistasis, Genetic
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Phenotype
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23346356
DOI: 10.1038/srep01099
PMCID: PMC3551227

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