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Article

Genome-wide epistasis analysis reveals significant epistatic signals associated with Parkinson's disease risk.

Brain : a journal of neurology - 3 Jun 2025

Cisterna-Garcia Alejandro, Bustos Bernabe I, Bandres-Ciga Sara, Leal Thiago P, Sarihan Elif I, Jok Christie, Krainc Dimitri, Mata Ignacio F, Lubbe Steven J, Botia Juan A

Abstract excerpt

Genome-wide association studies have increased our understanding of Parkinson's disease genetics by identifying common disease-associated variants. However, much of the heritability remains unaccounted for, and we hypothesized that this could be explained, in part, by epistasis, the statistical interaction between two or more genetic variants. Here, we developed a genome-wide non-exhaustive epistasis screening...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male
Middle Aged
alpha-Synuclein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cohort Studies

Epistasis, Genetic

Genetic Predisposition to Disease

Genome-Wide Association Study

Parkinson Disease

Polymorphism, Single Nucleotide

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 39657708
DOI: 10.1093/brain/awae398
PMCID: PMC12129738

Genes

MAPT
SNCA
WNT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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