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Article

Multi-locus penetrance variance analysis method for association study in complex diseases.

Human heredity - 1 Jan 2005

Sun Xiangqing, Zhang Zhongqi, Zhang Yulong, Zhang Xuegong, Li Yanda

Abstract excerpt

Common heritable diseases often result from the action of several different genes, each of which contributes to the total observed variability in the disease trait. Traditional single-locus association approaches rely heavily on the marginal effects of single-locus and tend to ignore the multigenic nature of complex diseases. The increasing request for localizing genes underlying traits in multi-gene diseases has...

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PMID: 16319491
DOI: 10.1159/000089868

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