Article

Genome-wide epistasis analysis in Parkinson’s disease between populations with different genetic ancestry reveals significant variant-variant interactions

2022-08-02

Abstract excerpt

Genome-wide association studies (GWAS) have increased our understanding of Parkinson’s disease (PD) genetics through the identification of common disease-associated variants. However, much of the heritability remains unaccounted for and we hypothesized that this could be partly explained by epistasis. Here, we developed a genome-wide non-exhaustive epistasis screening pipeline called Variant-variant interaction th...

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Literature Corpus work: e46e8464-97ec-53de-ae67-c04266a11081
DOI: 10.1101/2022.07.29.22278162

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