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Article

A Tool for Detecting Complementary Single Nucleotide Polymorphism Pairs in Genome-Wide Association Studies for Epistasis Testing.

Journal of computational biology : a journal of computational molecular cell biology - 1 Apr 2021

Caylak Gizem, Tastan Oznur, Cicek A Ercument

Abstract excerpt

Detecting interacting loci pairs has been instrumental to understand disease etiology when single locus associations do not fully account for the underlying heritability. However, the number of loci to test is prohibitively large. Epistasis test prioritization algorithms rank likely epistatic single nucleotide polymorphism (SNP) pairs to limit the number of statistical tests. Potpourri detects epistatic SNP pairs...

Topics

Algorithms
Epistasis, Genetic
Genome
Genome-Wide Association Study
Humans
Polymorphism, Single Nucleotide
Software

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33325775
DOI: 10.1089/cmb.2020.0430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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