The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.

doi:10.1016/s0092-8674(00)81225-8

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Article

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.

Cell - 10 Jul 1998

Kloss B, Price J L, Saez L, Blau J, Rothenfluh A, Wesley C S, Young M W

Abstract excerpt

The cloning of double-time (dbt) is reported. DOUBLETIME protein (DBT) is most closely related to human casein kinase Iepsilon. dbtS and dbtL mutations, which alter period length of Drosophila circadian rhythms, produce single amino acid changes in conserved regions of the predicted kinase. dbtP...

Topics

Amino Acid Sequence
Animals
Biological Clocks
Casein Kinase 1 epsilon
Casein Kinases
Conserved Sequence
Drosophila
Drosophila Proteins
Gene Expression Regulation
Genes, Insect
Genes, Lethal
In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insect Proteins

Models, Biological

Molecular Sequence Data

Mutation

Nuclear Proteins

Period Circadian Proteins

Source

Open in PubMed

Identifiers

PMID: 9674431
DOI: 10.1016/s0092-8674(00)81225-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9674431-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.PMID 9674431Read ↗

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