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Article

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.

Cell - 10 Jul 1998

Kloss B, Price J L, Saez L, Blau J, Rothenfluh A, Wesley C S, Young M W

Abstract excerpt

The cloning of double-time (dbt) is reported. DOUBLETIME protein (DBT) is most closely related to human casein kinase Iepsilon. dbtS and dbtL mutations, which alter period length of Drosophila circadian rhythms, produce single amino acid changes in conserved regions of the predicted kinase. dbtP mutants, which eliminate rhythms of per and tim expression and constitutively overproduce hypophosphorylated PER...

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Source

Identifiers

PMID: 9674431
DOI: 10.1016/s0092-8674(00)81225-8

Genes

DBT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.PMID 9674431Read ↗

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.Semantic proximity Read ↗

Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.Semantic proximity Read ↗

Casein kinase I: another cog in the circadian clockworks.Semantic proximity Read ↗

Activating PER repressor through a DBT-directed phosphorylation switch.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila.Semantic proximity Read ↗

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.Semantic proximity Read ↗

Molecular control of circadian behavioral rhythms.Semantic proximity Read ↗

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.Semantic proximity Read ↗

Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

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